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Similar content being viewed by others Introduction Obesity is a major chronic disease that continues to increase in prevalence worldwide and constitutes a key risk factor for development and progression of numerous related diseases including hypertension, dyslipidaemia and type 2 diabetes 1

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It attracts immune cells and endothelial cells to injury sites, stimulates angiogenesis (new blood vessel formation), promotes fibroblast proliferation and migration, and modulates the balance between metalloproteinases (which break down damaged tissue) and their inhibitors (which protect newly formed tissue)